Changes in version 1.3.3 (2026-09-28) - RN_iso_calc and RNentropy_iso_switch no longer return res, which duplicated gene_status and pv. - The default gene-level threshold of RN_iso_select (gene_pv) is now 0.05 (previously 0.01). - Corrected the package citation, which now lists the 2018 Nucleic Acids Research article and the 2021 Methods in Molecular Biology chapter. - Corrected and completed several help pages: an overview of both analyses in the package help, the exact testability rule of min_expr, cross-references between the isoform-switch functions, fixes to the dataset descriptions, and removal of outdated copies of the source code from the examples. Changes in version 1.3.2 - RN_iso_select now combines the sample p-values of each TESTED gene into a gene-level p-value with the Simes method and compares it with the threshold, without correction across genes. The threshold argument lpv_t is renamed gene_pv, the method argument and the lpv_adj component are removed, and the gene-level p-values are returned as gene_pv. selected reports the gene-level p-value (ISO_GENE_PV) next to the uncorrected per-sample p-values. - RN_iso_calc and RNentropy_iso_switch return the per-sample p-values as pv (formerly lpv), with columns named ISO_PV_ (formerly ISO_LPV_). - Renamed the sample columns of RN_IsoSwitch_Example_S7 and of the compact S7 example file to plain tissue names (brain, heart, kidney, liver, lung, muscle). Changes in version 1.3.1 - Added RN_iso_select to apply multiple-testing correction to isoform-switch local p-values and retain genes significant in at least one sample. - Added runnable file-based examples for the standard and isoform-switch workflows using a shared synthetic regression dataset. Changes in version 1.3.0 - Initialized the public GitHub development repository from the verified CRAN 1.2.3 release. - Added continuous integration and repository provenance metadata. - Added RN_iso_calc and RNentropy_iso_switch for the analysis of isoform switching, with explicit testability information and results validated against the independent C++ implementation. - Added the complete historical S7 isoform-switch example as the compressed RN_IsoSwitch_Example_S7 package dataset. Changes in version 1.2.3 (2022-04-13) - Fixed small bug in .RN_design_check preventing compatibility with R >=4.2.0 - Added reference to new publication - Removed unneeded initialization of .Random.seed - Fixed a few typos in the documentation - Added README.md, NEWS.md, and cran-comments.md files